Jake Gyllenhaal says he suffered a nasty injury while shooting the new “Road House” movie with Conor McGregor … revealing he cut his hand right open during an intense fight scene — and ended up with a staph infection.

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Armchair Expert with Dax Shepard

The Academy Award nominee and UFC superstar opened up on working together on set during a recent episode of “Armchair Expert” with Dax Shepard … and while they both praised each other’s professionalism, there was a bit of bad blood involved.

Gyllenhaal — who plays former MMA fighter Elwood Dalton in the flick — explained he was shooting an intense showdown with Conor’s character, Knox … and the scene involved a ton of breakaway glass.

As it turns out, it didn’t matter if it was real or fake … ’cause when Gyllenhaal put his hand down on the bar in the middle of the take, a piece went right through his mitt.

But, there was no quit in the lead actor — he said he trucked through the shot and finished the scene because they had already run through it several times and he knew this take was a good one.

Once the director called “cut” — shoutout irony — Gyllenhaal said he looked down at his hand and noticed his whole arm had swelled up … and he later found out it was a staph infection.

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Of course, staph can be a real pain in the ass … but it can also be deadly in some cases if it goes untreated.

Luckily, Jakey G is still kickin’ … and he said that was really the only injury he had while filming the Prime Video flick.

Conor ain’t the only big-name non-actor in the project — Post Malone also showed off his acting chops … and based on BTS pics, the musician got pretty bloody, too.

The movie hits the streaming platform on Thursday … so those queasy better be ready for some violence!!