John Mayer destroyed Anderson Cooper and Andy Cohen on CNN’s New Year’s Eve show … turning them into laughing hyenas as cat butts populated his side of the screen!

John joined the 2 best friends on the broadcast from a cat cafe in Tokyo. JM never made clear why alcohol mixes with felines, but even if he did it would not have made a difference.

Anderson couldn’t hold it together, as John used his deadpan humor at the Cats in the Box Cafe to render the 2 hosts unable to carry on a convo.

Maybe part of the reason is that CNN seems to have changed its “no drinking” policy because the 2 ACs were taking some pretty serious shots every hour.

A good time was had by all.