Oprah is gearing up to tackle a big topic in America in her upcoming TV special … namely, the impact prescription weight loss drugs are having on society, including herself.

The billionaire TV mogul says she will address medications and their relation to the weight loss revolution in her new ABC primetime special, “An Oprah Special: Shame, Blame and the Weight Loss Revolution” — which is set to air in a couple weeks.

Oprah’s special comes only weeks after she parted ways with WeightWatchers following a nearly 10-year partnership, leaving the weight loss company on the heels of criticism about proudly revealing she uses a weight loss drug.

As we reported … Oprah says she dropped 40 pounds last year, with the help of doctor-prescribed medication, though she’s never revealed the name of the drug she used.

Remember, Oprah using weight loss drugs was controversial because she previously labeled medications like Ozempic and Mounjaro an “easy way out” — and yet, she turned around and started taking them … although it’s unclear which of these drugs she’s on.

The TV special will explore questions and concerns about weight loss medications’ intended uses, side effects and their impacts on people living with obesity and diabetes.

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In a statement announcing the special, Oprah says … “It is a very personal topic for me and for the hundreds of millions of people impacted around the globe who have for years struggled with weight and obesity.”

Oprah continues … “This special will bring together medical experts, leaders in the space and people in the day-to-day struggle to talk about health equity and obesity with the intention to ultimately release the shame, judgment and stigma surrounding weight.”

The special airs March 18 at 8/7c on ABC and will be available for streaming the next day on Hulu.