When “South Park” drops a new special called, “The End of Obesity,” ya gotta know someone or something’s getting destroyed — and in this case, it’s weight loss drugs and Lizzo … via “body positivity.”

Here’s the deal … in the Paramount+ special, which started streaming Friday, the women of “South Park” (and, of course, the buffoon Randy), all turn to Ozempic to lose weight … while lying by saying they’re exercising to drop the lbs.

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Cartman, the iconic angry, fat kid on the long-running cartoon, wants some of that sweet Ozempic for himself — but since he doesn’t have diabetes, insurance won’t cover it, and he can’t afford the hefty price tag.

So, instead, like the other “poor” folks in town … he’s prescribed “Lizzo,” which is simply body positivity.

The tongue-in-cheek gag is … “taking” Lizzo makes people not care about how they look or their health. They can eat what they want and skip exercise, because they’re beautiful just the way they are.

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1/8/23

Twitter / @lizzo

Like most drugs, there are side effects to Lizzo … and “South Park” came up with a doozy. We’re not gonna describe it, except to say it involves music, ears and 💩.

As you’d expect, reactions are pretty mixed — some think the Lizzo bit is hilarious, but others wonder why creators Matt Stone and Trey Parker dislike her so much.